Bone mineral density and pathologic study of osteoporotic vertebral compression fracture

doi:10.3969/j.issn.2095-4344.2013.22.001

Abstract

Abstract:

BACKGROUND: Bone mineral density, as the osteoporosis criteria, has been widely used in clinical disease diagnosis, but its value of reflecting the changes of pathological characteristics of vertebral body fracture has not been explored.
OBJECTIVE: To observe the bone mineral density range and pathological features in different periods of osteoporotic vertebral compression fractures, and to verify the consistency of bone mineral density and pathology.
METHODS: Forty-five cases of osteoporotic vertebral compression fractures in imaging findings were divided into groups according to age, femoral neck and lumbar vertebral bone mineral density (T value) tests were performed before surgery, as well as the routine imaging test. Then, all the patients received percutaneous kyphoplasty, and the living tissues were obtained for the pathological section observation.
RESULTS AND CONCLUSION: Preoperative bone mineral density range tests showed that the bone mineral density was decreased with the increasing age; the pathological findings showed that with the reducing bone mineral density, the trabecular became thining and sparse, and the number was reduced, the space between trabeculars was widened; the arrangement was irregular with broken, disorder, or even necrosis, and fibrous tissue proliferation could be seen around the trabecular, and reactive new bone formation could be seen later. There was consistency between the bone mineral density decreasing trend and the pathological manifestations. The results indicate that the bone destruction staging of osteoporotic vertebral fractures is a progressive pathological process, while the decrease in bone mineral density may reflect the extent of vertebral compression damage.

Key words: bone and joint implants, basic experiment of spinal cord injury, osteoporosis, vertebral compression fractures, bone mineral density, pathology, compression fractures

CLC Number:

R318

Cui Jiang-chao, Sun Jian-min, Cui Xin-gang, Jiang Zhen-song. Bone mineral density and pathologic study of osteoporotic vertebral compression fracture[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(22): 3991-3997.

Figures/Tables 5

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